SPECIFICATIONS :
- First platform that correlates PK specific effects to PD endpoints
- Kinetic binding studies using in-vivo derived pharmacokinetic profiles
- Direct or indirect measurement of target modulation (investigated in their native form)
- Delivery of single or multiple drugs/biologics for schedule combination investigations or binding studies
How It Works
Specifications
-
LOW CELL COUNT
Requires <100 cells per well -
REAL-TIME TRACKING
Time lapse fluorescence imaging performed throughout study -
COMPLEX INFUSION PROFILES
Program infusion profiles with <5 min step sizes -
DELIVERY OF MULTIPLE DRUGS
Each drug stream is controlled independently -
IMMUNO- HISTOCHEMISTRY
Perform established staining protocols on-chip -
MOLECULAR ASSAYS
Recover cultured cells for assaying off-chip
NeoPKPD™
[In Development] Literature
Product Flyer
AAPS 2018 Poster
Guerrero et al., AAPS J. (2020)
